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In this work, we synthesized porous nanohydroxyapatite/collagen composite scaffold (nHA-COL), which resemble extracellular matrices in bone and cartilage tissues. Nano hydroxyapatite (nHA) was successfully nucleated in to the collagen matrix using hen eggshell as calcium biogenic source. Porosity was evaluated by apparent and theoretical density measurement. Porosity of all scaffolds was in the range of 95–98%. XRD and TEM analyses show the purity and size of nucleated HA around 10 nm and selected area electron diffraction (SAED) analysis reveals the polycrystalline nature of nucleated HA. SEM analysis reveals (i) all the scaffolds have interconnected pores with an average pore diameter of 130 micron and (ii) aggregates of hydroxyapatite were strongly embedded in the collagen matrix for both composite scaffolds compared with pure collagen scaffold. EDS analysis shows the Ca/P stoichiometric …
American Scientific Publishers
Publication date: 
1 Jan 2015

Sanosh Kunjalukkal Padmanabhan, Luca Salvatore, Francesca Gervaso, Massimo Catalano, Antonietta Taurino, Alessando Sannino, Antonio Licciulli

Biblio References: 
Volume: 15 Issue: 1 Pages: 504-509
Journal of Nanoscience and Nanotechnology